metoclopramid

   metoclopramid :- 

Is a dopamine antagonist

.  (Block c.t.z ) 

Accelerators intestinal transit and gastric emptying by preventing  relaxation  of gastric body and increasing  phasing activity  of antrum .

It decrease reflux in to esophagus.  


Uses (indication):- 




As antiemitic in : 
1⃣ - relief of symptoms of acute , recurrent  diabetic gastroparesis.  
2⃣ - relief of symptoms of treatment of heat burn and delayed gastric emptying .
3⃣ - treatment  of drugs related postoperative  N, V ( nausea , vomiting ) .
4⃣ - gasto-medication. 

Adverse Effects :- 

(side effects ) :

1- restlessness.
2- drowsiness 
3- depression , diarrhea  . 
4 - hypesprolactinaemia ( prolong admine )   
5- methaemoglobinaemia in G6PD deficiency.

Dosage and administration :-

Adults:
1 tablet three times daily before  meals . 

(The children's  dose should not exceed 0.5mg/kg body weight per day ) 

Contraindications :-

-Epilepsy. 
-GIT hemorrhage. 
-Mechanical obstruction or -perforation
-Co-administered anticholinergic.


Drug- interaction :- 

☝🏻 analgesics ➡ increase  absorption  by metaclopramide  . 

☝🏻 Anti- muscarinic ➡ antagonist  effect 

☝🏻anti- psychotic ➡ increase  risk of extrapyramidal  effects  . 


Dosage  form :-
▪Syrup .
▪Drops
▪Table
▪Injection  

Trade Name  :- 
Plemazol 10mg tab .drops
Primosan 10mg tab . Syr. Drops 
Metlazel  10mg tab . Drops 
Clopram  syrup . Drops .
Metoclopramid 10mg inj
Metamid 10mg inj .
Vomtin 10mg inj .
Vitamet 10mg inj .


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